The Best Natural Supplements for Pet Anxiety

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By Dr. Lila Brooks | Health & Wellness Column | The Pet Standard

Just like humans, pets can experience anxiety. Whether it's a thunderstorm, a visit to the vet, separation from their owner, or even a change in routine, our pets often react with visible distress.

This can manifest as trembling, pacing, excessive barking or meowing, hiding, destructive behaviour, or changes in appetite.

While behavioural training and environmental changes should always be considered first, natural supplements can play a supportive role in managing pet anxiety gently and effectively. These remedies are particularly beneficial for pets with mild to moderate anxiety or as part of a broader anxiety management plan.

In this article, we’ll explore the best natural supplements for pet anxiety, how they work, and when it may be time to consult your vet.

Understanding Pet Anxiety

Anxiety in pets especially dogs and cats is more common than many owners realise. Causes may include:

• Separation anxiety (being left alone)

• Noise phobias (e.g. fireworks, storms)

• Travel or vet visits

• Changes in household (moving house, new baby or pet)

• Rescue or shelter trauma in adopted animals

Left unmanaged, chronic anxiety can negatively impact your pet’s quality of life and even lead to health issues. Early intervention whether behavioural, environmental, or nutritional is key.

🌿 Why Choose Natural Supplements?

Natural calming supplements are generally safe, non-addictive, and gentle on the system. They’re not meant to sedate your pet but rather to promote relaxation and support the nervous system. Most are available over the counter, although it’s always advisable to check with your vet before introducing a new supplement especially if your pet is on medication.

1. L-Theanine (e.g. Zylkene, Anxitane)

Best for: General anxiety, noise sensitivity, separation issues

Available in: Capsules, chews, tablets

Price: ~£18–£30 depending on brand and size

How it works: L-Theanine is an amino acid found in green tea. It promotes the production of calming brain chemicals like dopamine and serotonin, without causing drowsiness.

Products like Anxitane and Zylkene (which also includes alpha-casozepine, a milk protein) are widely used in both dogs and cats for anxiety relief.

Pros:

• Well tolerated by most pets

• Can be used long-term or situationally

• Often recommended by vets

Cons:

• May take a few days to take effect

• Some pets may be picky with chews or capsules

2. Valerian Root & Chamomile

Best for: Situational stress (car rides, visitors, fireworks)

Available in: Liquid drops, chews, powders

Price: ~£10–£25

How it works: Valerian root and chamomile are traditional herbs known for their calming properties. They may reduce hyperactivity, promote sleep, and ease restlessness. Available in various forms, these herbs are often combined in natural calming blends.

Pros:

• Fast-acting for short-term anxiety

• Commonly found in “calming treats”

• Natural herbal solution

Cons:

• Some pets may be sensitive to the smell or taste

• Should not be used with sedatives unless advised by a vet

3. CBD (Cannabidiol)

Best for: Chronic anxiety, older pets with joint pain + anxiety

Available in: Oils, capsules, chews

Price: ~£25–£60 depending on strength and brand

How it works: CBD is derived from the hemp plant and works with the endocannabinoid system, which helps regulate mood, pain, and inflammation. It’s non-psychoactive (won’t get your pet “high”) and may be particularly helpful for anxious pets who also suffer from mobility issues or pain.

Pros:

• Promotes relaxation without sedation

• May also support joint health and inflammation

• Gaining popularity in veterinary care

Cons:

• Not all products are created equal look for lab-tested, pet-specific brands

• Regulations around CBD vary, so quality and legality can differ

Important note: Always consult your vet before using CBD, especially if your pet is on other medications.

4. Omega-3 Fatty Acids (e.g. Fish Oil)

Best for: General mental wellbeing and stress resilience

Available in: Oils, soft chews, capsules

Price: ~£15–£40

How it works: Omega-3 fatty acids particularly DHA and EPA are essential for brain function and have been shown to support calm behaviour in dogs. While not traditionally seen as a calming supplement, they play an important role in reducing inflammation, which may affect mood and behaviour.

Pros:

• Supports brain, heart, and coat health

• Beneficial for older pets and those with inflammation-related conditions

• Easy to mix with food

Cons:

• Can cause digestive upset if introduced too quickly

• Must be stored properly to avoid rancidity

5. Tryptophan (e.g. Calmex, Nutracalm)

Best for: Anxiety related to environmental changes or noise

Available in: Chews, powders

Price: ~£20–£35

How it works: Tryptophan is a natural amino acid that helps the brain produce serotonin, a key mood stabiliser. Supplements like Calmex often include a combination of tryptophan, magnesium, and B vitamins to enhance their calming effect.

Pros:

• Helps regulate mood and anxiety

• Often combined with other supportive ingredients

• Available without prescription

Cons:

• May not be suitable for pets with liver issues

• Effects can vary by pet

When to Seek Veterinary Advice

While natural supplements can be helpful, they’re not a cure-all. If your pet’s anxiety is severe, worsening, or interfering with their quality of life, it’s essential to speak with your vet. In some cases, behavioural therapy or prescription medication may be required.

Signs that warrant professional advice include:

• Aggression or self-injury

• Ongoing digestive issues related to stress

• Urinating or defecating indoors despite training

• Panic attacks (e.g. during storms or when left alone)

Final Thoughts

Supporting an anxious pet can be emotionally challenging, but you’re not alone and there are gentle, natural tools that can help.

The best natural supplements for pet anxiety are those that fit your pet’s individual needs, work in harmony with their lifestyle, and complement any behavioural or environmental strategies already in place.

Start slow, keep notes on any changes, and always follow dosing instructions. With time, patience, and the right support, many pets find relief and calm even during fireworks season.